三叶因子Ⅱ在不同胃黏膜病变中的表达及意义

Expression and Significance of TFF2 in Human Gastric Cancer and Precancerous Condition

目的:探讨三叶因子Ⅱ(Trefoil factors2,TFF2)在胃癌和癌前病变中的表达及临床意义。方法:应用免疫组化法检测120例经病理证实的正常胃黏膜组织20例,胃溃疡22例,慢性萎缩性胃炎24例和胃癌54例中TFF2的表达情况,对TFF2的平均光密度进行测定,并进行统计学分析。结果:TFF2在胃溃疡(0.365±0.018)和慢性萎缩性胃炎(0.370±0.023)中的表达较正常胃黏膜高(0.347±0.032),差异有统计学意义(P<0.05)。胃癌(0.327±0.020)中的表达低于前三者,差异有统计学意义(P<0.05)。TFF2的表达与分化程度、浸润深度有关(P<0.05)。结论:TFF2与肿瘤的发生密切相关,检测该指标可为胃癌诊断、判断预后和指导治疗提供理论依据。

Objective：To investigate the expression of Trefoil factors2 （TFF2） in gastric cancer and precancerous ailment and its possible clinical significance. Methods： The expression of TFF2 was studied by immunohistochemical SABC method in 120 gastric specimens including 20 normal groups, 22 gastric ulcers （GU）, 24 chronic atrophic gastritis （CAG） and 54 gastric cancers （GC）. The average light density was assayed by the expression of TFF2, and the statistic software was used to analyze the clinical data cor- related. Results： The average light density of TFF2 in gastric ulcer and chronic atrophic gastritis was higher than normal group. Compared with noImal group, significantly higher TFF2 was detected in gastric ulcer and chronic atrophic gastritis（ P 〈 0.05）. But the expression of TFF2 in gastric cancer was lower than the others（ P 〈 0.05） .The expression of TFF2 was significantly associated with the cellular differentiation and the depth of tumor invasion （ P 〈 0.05）. Conclusion： The TFF2 may play an important role in carcinogenesis and progression of gastric carcinoma. The detection of TFF2 can provide theoretical basis for diagnosing, evaluating prognosis and conducting cure of gastric cancer.