血清抗谷氨酸脱羧酶抗体对妊娠期糖尿病并发症及产后Ⅰ型糖尿病的影响

Expression of serum anti-glutamic acid decarboxylase antibody in gestational diabetes mellitus patients

目的检测谷氨酸脱羧酶抗体(GAD-Ab)在妊娠期糖尿病(GDM)患者中的表达,并评价其与产科并发症及临床预后的相关性。方法采用间接酶联免疫吸附法检测GAD-Ab。结果GDM组的血清GAD-Ab阳性率为12.5%,正常对照组GAD-Ab阳性率为2.08%,两者之间差异有统计学意义。结论在GDM患者中GAD-Ab阳性组更易并发羊水过多、巨大儿等产科并发症,产后易发生OGTT异常,易发生临床糖尿病。

Objective To find the expression of glutamie acid decarboxylase antibody （ GAD - Ab） in gestational diabetes mellitus, and to evaluate its relationship with obstetric complications and clinical prognosis. Methods GAD - Ab were detected by indirect enzyme - linked immunosorbent assay. Results The positive rate of GAD - Ab in GDM group was 12.5% and the positive rate of GAD - Ab in normal group was 2.08%, and there was significant difference （ P 〈 0.05 ）. Conclusion GAD - Ab - positive patients with GDM prone to polyhydramnios and macrosomia. The risk of post - natal development of type Ⅰ diabetes mellitus （T1DM） was significantly increased, especially those who need insulin therapy.