精氨酸衍生物对微循环的作用

Effect of Arginine Derivatives on Microcirculation

研究了精氨酸双糖甙（ＡＦＧ） 与精氨酸单糖甙（ＡＦ） 对兔微循环的作用。应用无麻醉条件下经动脉给予ＡＦＧ、ＡＦ，然后测定ＡＦＧ、ＡＦ对兔血压及其耳廓细动脉血流速度的影响。经口给予ＡＦＧ，１ ｈ 、２ ｈ 血液中未检出，ＡＦ分别为１ ．６ ｍｇ／１００ ｍ Ｌ 和３ ｍｇ／１００ ｍＬ；腿动脉给药，给予量ＡＦＧ １ ｍｇ／ｋｇ ，动脉血压下降为２－６７ ｋＰａ，持续１ ｍｉｎ。血流速度，ＡＦＧ 为１ ｍｇ／ｋｇ 时，从０ ．６ ｍ ｍ／ｓ 增加到１ ．２ ｍ ｍ／ｓ；２ ｍｇ／ｋｇ 时，从０ ．７ ｍ ｍ／ｓ增加到１ ．４ ｍ ｍ／ｓ。ＡＦ 为１ ｍｇ／ｋｇ 时，从０ ．７ ｍ ｍ／ｓ增加到１ ．９ ｍ ｍ／ｓ。因此认为，在无麻醉条件下，ＡＦＧ 与ＡＦ均能降低兔动脉血压，并能扩张血管。

To study effect of argininyl fructosyl glucose(AFG) and argininyl fructose(AF) on microcirculation of rabbit. Under no aneasthesia, AFG or AF was injected into femoral artery, the blood flow was observed with newly formed arteriole in rabbit's ear chamber. After AFG or AF was taken orally, AFG was not detected in blood plasma at 1 h and 2 h.The concentrations of AF were 1.6 mg/100mL and 3 mg/100mL in blood plasma,respectively at 1 h and 2 h.When AFG(1mg/kg) was injected into femoral artery, blood pressure dropped 2.67 kPa,kept up for one minute. AFG(1 mg/kg) elevated blood flow velocity from 0.6 mm/s to 1.2 mm/s. AFG( 2 mg/kg ): from 0.7 mm/s to 1.4 mm/s.AF(1 mg/kg): from 0.7 mm/s to 1.9 mm/s. So,under no aneasthesia, AFG or AF decreased blood pressure and improved microcirculation.