摘要
研究了精氨酸双糖甙(AFG) 与精氨酸单糖甙(AF) 对兔微循环的作用。应用无麻醉条件下经动脉给予AFG、AF,然后测定AFG、AF对兔血压及其耳廓细动脉血流速度的影响。经口给予AFG,1 h 、2 h 血液中未检出,AF分别为1 .6 mg/100 m L 和3 mg/100 mL;腿动脉给药,给予量AFG 1 mg/kg ,动脉血压下降为2-67 kPa,持续1 min。血流速度,AFG 为1 mg/kg 时,从0 .6 m m/s 增加到1 .2 m m/s;2 mg/kg 时,从0 .7 m m/s增加到1 .4 m m/s。AF 为1 mg/kg 时,从0 .7 m m/s增加到1 .9 m m/s。因此认为,在无麻醉条件下,AFG 与AF均能降低兔动脉血压,并能扩张血管。
To study effect of argininyl fructosyl glucose(AFG) and argininyl fructose(AF) on microcirculation of rabbit. Under no aneasthesia, AFG or AF was injected into femoral artery, the blood flow was observed with newly formed arteriole in rabbit's ear chamber. After AFG or AF was taken orally, AFG was not detected in blood plasma at 1 h and 2 h.The concentrations of AF were 1.6 mg/100mL and 3 mg/100mL in blood plasma,respectively at 1 h and 2 h.When AFG(1mg/kg) was injected into femoral artery, blood pressure dropped 2.67 kPa,kept up for one minute. AFG(1 mg/kg) elevated blood flow velocity from 0.6 mm/s to 1.2 mm/s. AFG( 2 mg/kg ): from 0.7 mm/s to 1.4 mm/s.AF(1 mg/kg): from 0.7 mm/s to 1.9 mm/s. So,under no aneasthesia, AFG or AF decreased blood pressure and improved microcirculation.
出处
《吉林农业大学学报》
CAS
CSCD
北大核心
1998年第4期45-47,共3页
Journal of Jilin Agricultural University
基金
中日合作项目
关键词
微循环
精氨酸衍生物
AFG
AF
argininyl fructosyl glucose
argininyl fructose
microcirculation