摘要
目的探讨特应性皮炎患者皮损内白介素-10(IL-10)的表达及其临床意义。方法采用荧光定量聚合酶链反应法测定20例特应性皮炎患者皮损内及16例正常对照者皮肤内IL-10 mRNA的定量表达,采用湿疹面积及严重度指数(EASI)评分评估患者病情,分析特应性皮炎患者皮损内IL-10mRNA的定量表达与EASI评分相关性。结果特应性皮炎患者皮损内IL-10mRNA的表达明显高于对照组皮肤内的表达(t=2.88,P<0.01);特应性皮炎患者皮损内IL-10mRNA的定量表达与EASI评分呈正相关(r=0.4743,P=0.0346)。结论IL-10mRNA的过度表达可能参与了特应性皮炎的发病。
Objective To investigate the expression and significance of interleutin-10（IL-10） mRNA in patients with atopic dermatitis（AD）.Methods 20 adult patients with AD and 16 health controls were sequentially enrolled in this study. The production of IL-10 mRNA was measured by fluorescent quantitative polymerase chain reaction（FQ-PCR）.The clinical signs of patients were measured by eczema area and severity index（EASI）.The correlation between expresion of IL-10 mRNA and EASI were analyzed.Results Expression of IL-10 mRNA in AD was significantly higher than that in health controls（t= 2.88,P0.01）.Significant positive correlation in AD were found between expression of IL-10 may take part mRNA and EASI scores（r=0.4743,P=0.0346）.Conclusion The over expression role of IL-10 may take part in pathogenesis of atopic dermatitis.
出处
《中国中西医结合皮肤性病学杂志》
CAS
2010年第1期30-32,共3页
Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine
