腭裂分子发病机制的新进展(英文)

Towards a molecular understanding of cleft palate

Cleft palate represents one of the major groups of congenital birth defects in the human population.Despite recent advancements in medical intervention,babies born with cleft palate often suffer multiple handicaps that signifi-cantly compromise the quality of their lives.Investigations of craniofacial development and malformations

Cleft palate represents one of the major groups of congenital birth defects in the human population. Despite recent advancements in medical intervention, babies born with cleft palate often suffer multiple handicaps that significantly compromise the quality of their lives. Investigations of craniofacial development and malformations utilizes different animal species as models as with other areas of research in developmental biology. Studies in mice combine the power of genetics and genome manipulation together with in vitro organ culture techniques leading to great progress in recent years. Furthermore, mouse models are extremely valuable in our effort to gain a better understanding of human craniofacial birth defects. The remarkable progress being made in the human genome,