MIM及其同源异构体MIM-B基因与肿瘤转移之间关系的研究进展

Updated correlation of homologous variants MIM and MIM-B with tumor metastasis

MIM(missing in metasastasis)又称MTSS1(metastasis suppresor 1),是一个新发现的肿瘤抑制基因,其中含有独立的肌动蛋白结合结构域。MIM-B是MIM的同源异构体,都定位于8q24.1,其编码蛋白都具有N末端的IRSP53/MIM同源结构域(IRSP53/MIM homology domain,IMD)和C末端的WH2结构,而WH2和IMD均可与细胞骨架蛋白结合,引起细胞骨架的改变从而调节细胞的生长活动。MIM或MIM-B在某些转移的肿瘤组织中不表达,而在多种正常组织中广泛表达,提示其可能具有肿瘤抑制作用。本文根据最新研究成果综述MIM和MIM-B两种同源异构体基因的结构、功能及抑制肿瘤转移的可能机制。

Missing in metastasis （ MIM）, also known as metastasis suppressor 1 （ MTSS1 ）, is a newly discovered cancer suppressing gene and characterized as an new actin-binding protein. MIM-B is a homologous variant of MIM. Both MIM and MIM-B are located on human chromosome 8q24.1 and consist of an N-terminal 250 -aa IRSP53/MIM homology domain （IMD） and a C-terminal WASP-homology domain 2 （WH2） , which are bound to the actin and regulate the changes of cytoskeleton and the growth of cells. MIM and MIM-B are expressed in normal surrounding tissues but not in some metastatic cancer cells, which suggests their cancer suppressing role. This paper updates the researches on MIM and MIM-B, focusing on their structures, functions and mechanism of suppressing cancer metastasis.