CB和MMP-2在上皮性卵巢癌中的表达及其相关性的研究

Expression and relationship of CB、MMP-2 in epithelial ovarian carcinoma

目的:探讨组织蛋白酶B(cathepsin B,CB)和基质金属蛋白酶-2(matrix metalloproteinases-2,MMP-2)在上皮性卵巢癌中的表达及其相关性。方法:采用免疫组化法检测60例上皮性卵巢癌组织、20例卵巢良性肿瘤、20例交界性上皮性卵巢肿瘤以及10例正常卵巢组织中CB和MMP-2的表达情况。结果:CB和MMP-2在正常卵巢组织、卵巢良性肿瘤、卵巢交界性肿瘤、上皮性卵巢癌中表达水平呈明显上升趋势,CB和MMP-2在上皮性卵巢癌中的表达与组织病理分级、淋巴结转移均呈正相关,与临床分期、组织学分型无关。二者在上皮性卵巢癌中的表达呈正相关。结论:CB和MMP-2表达升高在上皮性卵巢癌的发生、分化、进展过程中起重要的作用。

Objective：To study the expression and relationship of CB and MMP -2 in epithelial ovarian carcinoma. Methods ： Immunohistochemieal staining S - P method was used to detect the expression of CB and MMP - 2 in 60 cases of epithelial ovarian carcinoma,20 cases of benign ovarian tissue,20 cases of borderline ovarian tumor and 10 cases of normal ovarian tissue . Results ： The expression level of CB and MMP - 2 was obviously increased （ P 〈 0.001 ） in normal ovarian tissue, borderline ovarian tumor and epithelial ovarian carcinoma. The expressions of CB and MMP -2 were in positive correlation with tumor grade and lymphatic metastasis. ,while no correlation with tumor stage and histological grading. There was significant positive correlation between CB and MMP -2 in epithelial ovarian carcinoma. Conclusion ： The increased expression of CB and MMP - 2 may play an important role in the process of carcinogenesis, progression and differentiation of epithelial ovarian carcinoma. CB and MMP- 2 may be useful targets for treatment of ovarian carcinoma.