Kikuchi淋巴结炎的临床病理学观察

Clinicopathological features of Kikuchi's lymphadenitis

目的:探讨Kikuchi淋巴结炎的病因及临床特征,提高对Kikuchi淋巴结炎的认识,减少误诊。方法:对31例病理确诊为Kikuchi淋巴结炎的病例,结合临床特点和免疫组化进行分析观察。结果:31例中男性14例,女性17例,临床表现均为发热和浅表淋巴结肿大。所有的病例可见核碎片及淋巴细胞凋亡;淋巴结内出现片状或灶状形态多样的组织细胞增生。免疫组化标记CD45、CD68及CD3均为阳性表达。结论:本病病理形态以组织细胞增生为特征,主要是与组织细胞来源的淋巴瘤进行鉴别,免疫组化标记CD68及CD3阳性表达,对本病诊断有很重要的价值。该病属自限性疾病,预后多良好。

Objective：To investigate the cause of Kikuchi＇s lymphadenitis and clinical characteristics. Methods： Thirty one cases with Kikuchi lymphadenitis, were analysed for the clinical features. Results： Among 31 cases, 14 male, 17 female. High fever and superficial lymph nodes can be seen in all cases also lymphocyte apoptosis nuclear debris;numerous polymorphical histiocyte proliferation in focal or lange areas were visualized. CD45, CD68 and CD3 were positive in 31 cases. Conclusion：Lymphnode focal necrosis and histiocytic proliferation are featares of Kikuchig lymphadenitis. CD68 and CD3 expression has very important value for HNl＇s diagnosis. The disease is self - limited disease, most patients have good prognosis.