吗啡持续静注用于恶液质合并重度癌痛治疗的安全性研究

Safety and effect of continuous intravenous morphine pumping for severe cancer pain patients with cachexia

目的:观察吗啡持续静脉微泵注射用于恶液质合并重度癌性疼痛患者的安全性与有效性。方法:49例晚期肿瘤患者,均呈恶液质状态,合并重度癌性疼痛,经口服吗啡或外贴芬太尼治疗效果欠佳。使用微量注射泵给予吗啡持续静脉注射,治疗起始给予吗啡滴定治疗,治疗前后采用数字疼痛强度分级法(NRS)对疼痛程度进行评估,生活质量评分(QOL)评价生活质量,观察记录不良反应。结果:在吗啡持续静脉注射治疗期间,未发生严重不良反应,所有患者疼痛显著缓解,生活质量明显改善。结论:吗啡持续静脉微泵注射治疗可以安全应用于恶液质合并重度癌性疼痛的患者,未见严重不良反应,起效迅速,疗效确切。

Objective：To evaluate the safety and effect of continuous intravenous morphine pumping for severe cancer pain patients with cachexia. Methods： Total of 49 severe cancer pain patients with cachexia were studied,who failed to the oral and transdermal opiates treating. Morphine was continuously infused intravenously via volumetric infusion pump,and the daily initial dosage started from 80 -200mg/d. Before and after the therapy we evaluated the NRS score and QOL score of the patients. Results： During the therapy, no patients had severe side effect. All patients pain were relieved and QOL was improved. Condusion： Continuous intravenous morphine pumping is a safe and effective method for relieving severe cancer pain with cachexia.