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Claudin在胃肠道肿瘤发生发展中的作用 被引量：1

The role of Claudin in development of gastric and colorectal tumour
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摘要 Claudin是维持紧密连接结构和功能最重要的蛋白分子,在胃肠道肿瘤的发生发展及临床诊治中起着重要的作用。本文收集国内外近年来有关Claudin的分子结构及在胃肠道肿瘤发生发展中作用的最新文献并作综述。 Claudin is one of the major structural elements within the tight junction apparatus which is indispensable in maintaining its biological functions and could possibly be a useful tumor marker and targeted for cancer therapeutics. In this paper, the literatures on the molecular structure and functions of Claudin were reviewed.
作者 邱江锋 张志奇 吴志勇
机构地区 福建医科大学附属厦门第一医院肿瘤外科 上海交通大学医学院仁济医院普外科
出处 《现代肿瘤医学》 CAS 2010年第3期591-593,共3页 Journal of Modern Oncology
基金 福建省创新基金课题(2007-CXB-11)
关键词 紧密连接 CLAUDIN 胃肠肿瘤 发病机制 tight junction Claudin gastric and colorectal tumor pathogenesis
分类号 R753.2 [医药卫生—皮肤病学与性病学]
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参考文献39

  • 1Hossain Z, Hirata T. Molecular mechanism of intestinal permeability: interaction at tight junctions [ J ]. Mol Biosyst, 2008,4 ( 12 ) : 1181 - 1185.
  • 2Lee DB, Huang E, Ward HJ. Tight junction biology and kidney dysfunction [ J ]. Am J Physiol Renal Physiol, 2006,290 ( 1 ) : F20 - 34.
  • 3Tsukita S, Yamazaki Y, Katsuno T, et al. Tight junction - based epithelial microenvironment and cell proliferation [ J]. Oncogene, 2008,27 (55) :6930 - 6938.
  • 4Van Itallie CM, Anderson JM. The molecular physiology of tight junction pores[ J]. Physiology,2004,19:331 - 338.
  • 5Furuse M,Fujita K,Hiiragi T,et al. Claudin- 1 and -2:novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin[ J]. J Cell Biol, 1998,141 (7) : 1539 - 1550.
  • 6hoh M, Furuse M, Mofita K, et al. Direct binding of three fight junction - associated MAGUKs, ZO - 1, ZO - 2, and ZO - 3, with the COOH termini of claudins [ J]. J Cell Biol, 1999, 147 (6) : 1351 - 1363.
  • 7Yu AS, Cheng MH, Angelow S, et al. Molecular basis for cation selectivity in claudin - 2 - based paracellular pores: identification of an electrostatic interaction site[J].J Gen Physiol,2009,133 ( 1 ) : 111 - 127.
  • 8Nitta T, Hata M, Gotoh S, et al. Size - selective loosening of the blood -brain barrier in claudin -5 -deficient mice [ J ]. J Cell Biol,2003,161 ( 3 ) :459 - 460.
  • 9Kurasawa M, Kuroda S, Kida N, et al. Regulation of tight junction permeability by sodium caprate in human keratinocytes and reconstructed epidermis [ J ]. Biochem Biophys Res Commun, 2009,381 (2) :171 -175.
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现代肿瘤医学
2010年 第3期

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