环氧化酶-2与肾癌的研究进展

Advances in researches on cyclooxygenase-2 in renal cell carcinoma

现已证实,环氧化酶2(COX-2)不仅参与炎症反应,在多种恶性肿瘤亦有不同程度的表达。目前许多临床前期实验皆证实COX-2通过多种致癌机制在肾癌的发生、发展、转移和预后中扮演很重要的角色。因此,COX-2成为当前研究治疗肾癌的新靶点之一。国外学者已针对COX-2抑制剂在肾癌治疗的应用进行了临床试验。本文就COX-2与肾癌的关系和COX-2抑制剂在肾癌临床应用中的研究进展综述如下。

It has already been proved that cyclooxygenase 2 （COX -2） not only participates in inflammatory reactions,but also expresses in different malignancies in different degrees. Several preclinical experiments have proved COX- 2 takes an important role in the pathogenesis, progress, metastasis and prognosis of renal cell carcinoma through different mechanisms. It has been a new research subject in the treatment of renal cell carcinoma. Clinical experiments are carried out in foreign countries concerning the use of COX -2 inhibitors in renal cell carcinoma. This article summarizes the research advances on the relationship between COX -2 and renal cell carcinoma and the clinical application of COX - 2 inhibitors in the treatment of renal cancer.