动脉粥样硬化血管内皮分泌功能失调与平滑肌细胞增殖

The cause of atherosclerosis:secretory dysfunction in vascular endothelial cells and proliferation of smooth muscle cells

血管内皮细胞和平滑肌细胞是血管壁两种主要细胞,两者在结构上和功能上有着密切的关系,动脉粥样硬化的发生源于循环因子和血管壁细胞间的相互作用,内皮细胞损伤等所导致的分泌功能失调和平滑肌细胞的异常增殖而引起的血管腔狭窄和痉挛是动脉粥样硬化等多种血管疾病发生发展的共同病理基础。本文从动脉粥样硬化病理状态下血管内皮分泌的生长因子、细胞因子、血管活性物质对平滑肌细胞增殖影响的最新研究进展做一综述。

Abstract：Vascular endothelial cells and smooth muscle cells, structurally and functionally closely related, are two main cells of vascular wall. While the interaction between cycling factors and vascular wall cells can lead to the occurrence of atherosclerosis. The injury of endothelial cells results in secretory dysfunction and abnormal proliferation of smooth muscle cells which narrows the cavity of blood vessel and cause spasm. This is the common pathological basis of the occurrence and development of atherosclerosis and other vascular diseases. In the pathological state ofatherosclerosis, the proliferation of smooth muscle cell will be af- fected by what the vascular endothelial cells secrete, like growth factors, cytokines, and vasoactive substances. This paper gives a comprehensive overview of the latest research advances in this field.