摘要
群体药动学(PPK)应用统计学原理,综合评价影响药动学个体间及个体内差异的各种因素,进一步利用Bayesian反馈,能够较为准确地预测患者个体药动学参数。PPK在免疫抑制剂环孢素、他克莫司、霉酚酸及西罗莫司的合理用药均有广泛应用。
Population pharmacokinetics ( PPK ), which is based on the principle of statistics, can be used to estimate various inter- and intra-individual factors which affect pharmacokinetics. By using Bayesian estimator, PPK can predict individual pharmacokinetic parameters accurately. PPK is widely used in the im-munosuppressive therapy with cyclosporine, tacrolimus, mycophenolle acid and sirolimus.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2010年第2期159-163,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30500626)
关键词
群体药动学(PPK)
免疫抑制剂
环孢素A
他克莫
司
霉酚酸
西罗莫司
population pharmaeokinetics ( PPK )
immunosuppressive drugs
cyclosporine A
tacrolimus
myphonolic acid
sirolimus