探讨小儿维生素K缺乏症的几种因素

Discusses young child Vitamin K deficiency＇s several kind of factors

维生素K缺乏之所以导致出血是由于Ⅱ，Ⅶ，Ⅸ，Ⅹ等凝血因子主要在肝微粒体内合成，在此过程中须维生素K参与，这些凝血因子前体蛋白的谷氨酸残基才能r-羧基化，羧基型蛋白具有更多的钙离子结合位点，然后方具凝血的生物活性，当维生素K缺乏时，上述维生素K依赖因子不能羧化，只是无功能的蛋白质，因此不能参与凝血过程而致出血。本病特点为突发出血，根据出血时间分为3型。

The reason that Vitamin K lacks causes the hemorrhage is＇ because hemoglutination factors and so onⅡ,Ⅶ,Ⅸ,Ⅹ mainly synthesize in the liver microsome, during this process must the Vitamin K participation, these hemoglutination factor precursor protein glutanic acid residue be able the r- carboxylation, the carboxyl group protein to have more calcium ion union position spot, however rear area hemoglutination biological activity, when Vitamin K lacks, the above Vitamin K dependence factor cannot suo, only be the non-function protein, therefore cannot participate in the hemoglutination process sending the hemorrhage . This sickness characteristic to arise suddenly the hemorrhage, divides into according to the bleeding time 3.