摘要
目的研究生殖道支原体感染与女性不孕不育之间的关系,分析其耐药情况。方法采用培养的方法对我院生殖中心就诊的不孕不育女性患者宫颈分泌物进行检测。结果不孕不育组的Uu、Mh感染率与对照组比较有显著差异(P<0.05),明显高于对照组;对喹诺酮类药物氧氟沙星(OFL)、左氧氟沙星(LEV)和司帕沙星(SPA)的耐药率呈较高水平,大环内酯类药物阿奇霉素(AZI)和罗红霉素(ROX)耐药率较高,尤其在解脲脲原体(Uu)+人型支原体(Mh)混合感染中,喹诺酮类和大环内酯类的耐药率均在高水平状态,四环素类抗生素在混合感染中耐药率显著上升。结论女性不孕不育与生殖道支原体感染有密切的关系,强力霉素(DOX)、美满霉素(M IN)和交沙霉素(JOS)为治疗支原体的首选药物。
Objective： To investigate the association of ureaplasma urealyticum （Uu） and mycoplasma hominis （Mh） infection in infertile women, discuss the drug resistance of mycoplasma. Methods ： Uu and Mh were detected respectively in the infertile women in the Reproductive Medicine Centre of our hospital. Results ： The infection rates of Uu and Mh in infertile group were significantly higher than those in the control （ P 〈 0. 05） ; and drug resistance to commonly used antibiotics of Du - 6859a （ OFL, LEV and SPA） was high, MIs antibiotics （AZI , ROX ） had a high drug - resistanc rate, especially in the patients of Mh and Uu mixed positive , the drug - resistance rates of quinolones and MIs antibiotics were high persistently, the drug - resistance rates of tetracycline antibiotics increased greatly. Conclusion： There was closely correlation between mycoplasma infection in female infertility, and deoxycycline, minocycline and josamycin were the first choice drug to cure mycoplasma.
出处
《中国优生与遗传杂志》
2010年第1期118-119,共2页
Chinese Journal of Birth Health & Heredity
关键词
支原体感染
不孕不育
耐药性
Mycoplasma infection
Infertility
Drug Resistance
