冠心病患者血清中超敏C反应蛋白和IL-18的表达及相关性

Serum levels of hs-CRP and IL-18 in coronary heart disease and their clinical significance

目的检测冠心病患者血清中超敏C反应蛋白（hs—CRP）和IL-18的表达情况，探讨其临床意义。方法选取我院收治的81例冠心病患者f冠心病组）及20例体检健康成人（对照组），分别检测两组对象血清中hs—CRP（以免疫荧光法测定）及IL-18（以酶联免疫吸附实验法测定）的含量，并作组间比较及相关性分析。结果冠心病组患者hs—CRP及IL-18含量均显著高于对照组（均P〈0．01）。冠心病组中心肌梗死患者hs—CRP及IL-18含量均显著高于稳定型及不稳定型心绞痛患者（均P〈O．01）。但稳定型与不稳定型心绞痛患者问hs—CRP及IL-18含量并无明显差异（均P〉0.05）。线性相关分析结果显示，冠心病组患者hs—CRP与IL-18的表达呈明显正相关（r=0．402，P〈0.05），而对照组hs—CRP与IL-18的表达无相关性（P〉0.05）。结论hs—CRP及IL-18在冠心病患者中呈现高表达，在冠心病的发生、发展中发挥着重要作用，联合检测hs—CRP及IL-18对于判断冠心病患者的病变程度具有重要意义。

Objective To investigate the serum levels of hs-CRP and IL-18 in coronary heart disease and their clinical significance. Methods The study included 81 cases of coronary heart disease （experimental group） and 20 normal adults （control group）. The serum levels of hs-CRP were detected by immunofluorescence and IL-18 by ELISA. Results Serum levels of hs-CRP and IL-18 in experimental group were significant higher than those in control group. Furthermore serum hs-CRP and IL-18 were higher in patients with myocardial infarction than those in patients with stable and unstable angina pectoris; but there were no significant differences between stable and unstable angina pectoris patients, Serum hs-CRP was positively correlated with IL-18 levels Jn coronary heart disease. Conclusion The higher expressions of IL-18 and hs-CRP may promote the development of coronary heart disease. The combined examination of hs-CRP and IL-18 may be helpful to predict the severity of coronary heart disease.