摘要
目的探讨黄色滤光片对窄谱蓝光照射大鼠视网膜功能的保护作用。方法选取20只雄性健康SD成年大鼠，左眼给予黄色滤光片蓝光过滤后照射1h，右眼给予窄谱蓝光照射1h，分别记录照射前及照射后1、2、7d左、右眼视网膜电图（ERG），并测定相应的a、b波峰值，分析其变化情况。结果照射前后左眼的ERGa、b波峰值并无明显变化（均P〉0．05）；照射后1、2、7d右眼的ERGa、b波峰值均明显低于照射前（均P〈0．05），而照射后1、2、7d右眼的ERGa、b波峰值均无明显变化（均P〉0．05）。结论窄谱蓝光照射可以引起大鼠视网膜功能不可恢复性下降，而黄色滤光片对视网膜功能具有一定的保护作用。
Objective To investigate the protective effects of yellow filter against blue light-induced retinal damage in rats. Methods Twenty adult male SD rats were included in the study; the left eyes were covered with yellow filter and right eyes not, both eyes were exposed to narrow spectrum blue light for 1 h. The flash eye electroretinogram （ERG） was undertaken in dark and b wave peak were measured at d 1, 2 and 7 after exposure to blue light. Results There was no difference in ERG a and b wave peak between right and left eyes before exposure. ERG a and b wave peak of the right eye decreased at d 1, 2 and 7 after exposure and ERG of the left eye had no changes. Conclusion The wide spectrum of blue-ray exposure can cause irreversible retinal damage in rats, which can be protected by yellow filter.
出处
《浙江医学》
CAS
2010年第1期71-72,共2页
Zhejiang Medical Journal
