基于生理解剖知识的入睡机制神经元群网络模型研究

STUDY OF MODELING OF NEURON NETWORK FOR MECHANISM OFFALLING ASLEEP BASED ON PHYSIOLOGICALAND ANATOMICAL KNOWLEDGE

以生理解剖知识为基础，在已有的丘脑网状核细胞和丘脑皮质细胞间组成的入睡机制的两细胞环路模型［１］和由此两细胞环路组成的网络模型［２］的基础上，提出了增加皮层细胞在内的三种细胞组成的环路模型和网络模型，以使模型更符合近来认为睡眠机制是皮层和丘脑环路中出现特定的同步振荡的看法［３］。并能使模型的仿真结果可以和规定人体睡眠分期的脑电特征波相对应。这一网络模型的仿真结果，在一定条件下，确能在皮层细胞处出现符合睡眠分期中规定的标志入睡的纺锤波，这一初步结果，启示我们用模型仿真方法来进一步探讨睡眠机制和用模型仿真方法来进一步探讨人脑的微观神经元的电活动是如何通过同步振荡整合到宏观功能状态的某些信息处理过程的可能性。

Based on the physiological and anatomical knowledge, and the two-neuron circuit model which is made of a reticular neuron and a thalamocortical neuron in thalamus, a cortical neuron has been added to form a model of three-neuron circuit. According to this three-neuron circuit model, a network model has also been provided in this paper to make our models more coincident with the modern sleeping mechanisim. The network modeling may lead us to compare the simulation results with the human sleep EEG waveform. Our simulation results show that in some cases, the network model can generate the spindle waveform which is an electrographic mark for falling asleep. This results may enlighten us that it is possible to use the simulation results of these models to search for the further sleeping mechanism and the information processing about how the microscopical electric activities in billions of synaptically coupled neurons can be integrated to the macroscopical function states by synchronized oscillations in human brain.