摘要
虎纹捕鸟蛛毒素ＨＷＴＸ－Ｉ（５ｍｇ／Ｌ）对电刺激豚鼠回肠引起的一过性收缩有非常明显的抑制作用．ＨＷＴＸ－Ｉ的抑制作用发生后，乙酰胆碱（ＡＣｈ）诱发的回肠收缩幅度与使用ＨＷＴＸ－Ｉ前无明显差异．在使用酚妥拉明后，ＨＷＴＸ－Ｉ仍能抑制豚鼠回肠的一过性收缩．
The contraction of isolated guinea pig ileum induced by electrical stimulus can be inhibited by huwentoxin I(HWTX I), a peptide toxin purified from the Chinese bird spider Selenocosmia huwena. After blockage, the amplitude of the contraction of the ileum induced by certain concentration of ACh is almost the same as that before adding HWTX I. Phentolamine can not change the inhibition effect of HWTX I on guinea pig ileum. These results indicate that the inhibition effect of HWTX I on guinea pig ileum is due to blockage of the release of ACh or affecting the process before ACh release.
出处
《生命科学研究》
CAS
CSCD
1998年第4期273-277,共5页
Life Science Research
基金
国家自然科学基金
国家"八六三"计划资助
