136例中药制剂不良反应报告分析

Analysis of 136 Cases of Adverse Drug Reactions Induced by Traditional Chinese Medicine

目的:了解我院中药制剂致药品不良反应(ADR)发生的特点与一般规律。方法:对我院2004年1月～2009年6月收集到的中药制剂致136例ADR报告进行汇总分析。结果:引起ADR的中药制剂涉及38个品种。136例ADR中,41～70岁构成比最高,占71.32%;以静脉滴注给药途径引起的ADR最常见(占68.38%);ADR涉及的器官或系统主要为皮肤及其附件;绝大多数ADR转归良好。结论:中药制剂发生ADR与多种因素相关。临床在使用时应引起足够的重视,以减少ADR的发生。

Objective：To investigate the characteristics and regularities of adverse drug reactions（ADR） induced by traditional chinese medicine in our hospital. Methods： 136 ADR cases induced by traditional chinese medicine and collected by the ADR monitoring center in our hospital from 2004 to June 2009 were classified and analyzed. Results： 38 kinds of traditional chinese medicine were involved in the total 136 ADR cases, of which, those patients aged above 41-70 years accounted for 71.32%. 68.38% of the total 136 cases were induced by the intravenous route. The lesions of skin and its accessories were the predominant presentation of ADRs. The majority of the ADR cases had a good turnover. Conclusion： Multiple factors contributed to the ADR, to which great importance should be attached so as to reduce the incidence of ADR induced by traditional chinese medicine.