阿斯匹林与尼莫地平合用对血小板聚集的影响

Effects of combination of aspirin and nimodipine on platelet aggregation

目的观察阿斯匹林与尼莫地平合用对兔体外和大鼠半离体血小板聚集的影响。方法用比浊法测量血小板的聚集率。结果在体外和半离体实验中，两药合用均有浓度（剂量）依赖性地抑制由二磷酸腺苷（ADP）和胶原诱导的血小板聚集，合用后Q值均大于1。结论阿斯匹林与尼莫地平合用有协同抑制血小板聚集作用。

AIM To study the effects of combination of aspirin (ASP) and nimodipine (Nim) on platelet aggregation in vitro in rabbit and in vivo in rat. METHODS Aggregation test was performed by light transmission. RESULTS Combination treatment of ASP and Nim concentration (dose )-dependently inhibited platelet aggregation induced by ADP and collagen in vitro and in vivo, Q values were more than 1. CONCLUSION Combination of Asp and Nim had synergistic inhibitory effects on platelet aggregation.