当归多糖铁大鼠体内药动学参数与给药剂量的关系

The relationship between the pharmacokinetic parameters and dose of Angelica sinensis polysaccharide-iron complex in rats

目的:研究当归多糖铁(Angelicasinensis polysaccharide-iron complex,APIC)在正常SD大鼠体内的药动学,探讨A-PIC单次给药剂量与药动学参数之间的关系。方法:大鼠灌胃给予APIC溶液,采用原子吸收法测定各时间点血清铁浓度,用DAS2.0软件求算药动学参数。结果:血药浓度-时间数据符合二室模型,t1/2α,t1/2β,t1/2Ka,tmax,Cmax随剂量增加无显著性变化,但CL/F随剂量增加而增大,AUC(0-7)与剂量不呈线性关系:当剂量小于5.83mg.kg-1时,AUC随着剂量的增加而增大,当剂量大于5.83mg.kg-1时,各剂量组AUC差异无显著性。结论:表明APIC不呈线性吸收,为优化铁剂给药方案提供依据。

OBJECTIVE To study the pharmacokinetics of Angelica sinensis polysaccharide-iron complex（APIC） in rats after intragastric administration and the relationship between the pharmacokinetic parameters and the dose. METHODS Serum iron concentration were assayed by atomic absorption spectrometry, the pharmacokinetic paramelers were analyzed by DAS2.0 program. RFNULTS The concentration-time curves of APIC were fitted to two-compartment open model, The t1 2α,t1 2β,tt/2Ka,tmax,Cmax had no obvious difference, but CL/F increases as the dose increases. AUC was not linear correlation with dose： when the dose is less than 5.83 mg·kg^-1, AUC increases as the dose increases; when the dose is greater than 5.83 mg·kg^-1 , AUC of each dose group had no significant difference. CONCLUSION APIC does not show the linear absorption, the dose pharmacokinetic parameters of iron can be used to optimize the dosage regimen.