共沉淀法制备高纯度纳米羟基磷灰石的研究

Preparation of High Quality Nano-hydroxyapatite Powder by Coprecipitation Method

纳米羟基磷灰石(HAP)是生物材料领域研究的热点问题之一,其制备条件直接影响其生物活性和生物相容性。该文采用共沉淀法,以Ca(NO3)2.4H2O、(NH4)2HPO4分别为钙、磷源,用氨水调控溶液酸度合成了纳米HAP晶体;系统地研究了温度、浓度、酸度、搅拌速度、静置时间等对HAP纯度和晶体形貌的影响;采用SEM、XRD对所得HAP进行了表征。结果表明,温度和酸度为主要影响因素。适宜的合成条件为:70℃,Ca(NO3)2.4H2O、(NH4)2HPO4溶液初始浓度为0.10 mol/L,10≤pH≤11,搅拌速度300 r/m in,静置24 h,在不加分散剂的条件下得到的晶体分散性好,颗粒均匀。

The preparation of nano-hydroxyapatite（nano-HAP） is one of the hottest topics in the biomaterial field.The bioactivity and biocompatibility of nano-HAP were greatly affected by temperature,pH value,and concentrations of raw materials.In this study,nano-HAP powder was prepared by the co-precipitation method using calcium nitrate hydrated（Ca（NO3）2·4H2O） and di-ammonium hydrogen phosphate（（NH4）2HPO4） as starting materials and ammonia solution as a pH adjustment agent.Factors affecting the size and morphology of the nano-HAP crystal were systematically studied.The obtained powders were characterized using X-ray diffraction and scanning electron microscopy.Results showed that the acidity and temperature were two major factors.The optimal temperature was 70 ℃ and both the concentrations of Ca（NO3）2·4H2O and（NH4）2HPO4 were 0.1 mol/L,respectively.The pH value was between 10 and 11.The stirring rate was 300 r/min,and the aging time was 24 h.The dispersion and uniformity of the obtained product were superior to those of the reported ones.