期刊文献+

角朊细胞在口腔黏膜免疫反应中的作用

原文传递
导出
摘要 角朊细胞(keratinocyteS,KC)是皮肤、口腔、食管、肛门和阴道等部位被覆上皮的主要组成细胞。KC的分化成熟过程复杂且受多基因的严密调控.并伴随一系列形态学变化。最终形成完整的上皮结构.为机体提供机械性理化屏障而成为机体抵御外源性病理因素的第一道防线。与此同时.以皮肤KC为代表的相关研究表明.KC以抗原呈递细胞、免疫效应细胞及靶细胞等多种方式.参与机体的免疫防御反应。而口腔黏膜除在胚层发生、组织结构和功能等方面与皮肤有许多相似之处以外.本课题组和其它近年研究发现.口腔黏膜KC在免疫反应中的作用也与皮肤KC相类似。
出处 《中华口腔医学研究杂志(电子版)》 CAS 2010年第1期1-4,共4页 Chinese Journal of Stomatological Research(Electronic Edition)
基金 国家自然科学基金(30872874 30672317) 教育部博士点基金(200805580082) 广东省自然科学基金(8151008901000080)
  • 相关文献

参考文献12

  • 1Wenzhao Liu,Hongxia Dan,Zhi Wang,Lu Jiang,Yu Zhou,Man Zhao,Qianming Chen,Xin Zeng.IFN-Gamma and IL-4 in Saliva of Patients with Oral Lichen Planus: A Study in an Ethnic Chinese Population[J].Inflammation.2009(3)
  • 2Kerstin Wolk,Harald S. Haugen,Wenfeng Xu,Ellen Witte,Kim Waggie,Monica Anderson,Elmar Baur,Katrin Witte,Katarzyna Warszawska,Sandra Philipp,Caroline Johnson-Leger,Hans-Dieter Volk,Wolfram Sterry,Robert Sabat.IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not[J].Journal of Molecular Medicine.2009(5)
  • 3Byrne AM,Goleva E,Leung DY.Identification of glucocorticoid-induced TNF receptor-related protein ligand on keratinocytes:ligation by GITR induces keratinocyte chemokine production and augments T-cell proliferation[].Journal of Investigative Dermatology.2009
  • 4Wittmann M,Zeitvogel J,Wang D,et al.IL-27is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes[].The Journal of Allergy and Clinical Immunology.2009
  • 5Sanmiguel JC,Olaru F,Li J,et al.Interleukin-1regulates keratinocyte expression of T cell targeting chemokines through interleukin-1receptor associated kinase-1(IRAK1)dependent and independent pathways[].Cellular Signalling.2009
  • 6Peyret-Lacombe A,Brunel G,Watts M,et al.TLR2sensing of F.nucleatum and S.sanguinis distinctly triggered gingival innate response[].Cytokine.2009
  • 7Ohta K,Shigeishi H,Taki M,et al.Regulation of CXCL9/10/11in oral keratinocytes and fibroblasts[].Journal of Dental Research.2008
  • 8Youngnak-Piboonratanakit P,Dhanuthai K,Thongprasom K,et al.Expression of IFN-gamma before and after treatment of oral lichen planus with0.1%fluocinolone acetonide in orabase[].Journal of Oral Pathology and Medicine.2009
  • 9Scully C,Bagan J.Oral mucosal diseases:erythema multiforme[].British Journal of Oral and Maxillofacial Surgery.2008
  • 10Marzano AV,Tourlaki A,Merlo V,et al.Herpes simplex virus infection and pemphigus[].Int J Immunopathol Pharmacol.2009

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部