期刊文献+

T细胞活化及共刺激分子信号转导与动脉粥样硬化的关系 被引量:4

下载PDF
导出
摘要 T细胞介导的针对斑块抗原的适应性免疫应答反应是动脉粥样硬化(AS)一系列炎症反应的主要环节。初始T细胞接受抗原后的活化必须依赖T细胞共刺激分子介导的共刺激信号通路。通过调控T细胞共刺激分子抑制T细胞介导的炎症反应可延缓动脉粥样硬化的进程,为动脉粥样硬化的免疫治疗提供了新的靶点。
出处 《医学信息(中旬刊)》 2010年第2期438-439,共2页 Medical Information Operations Sciences Fascicule
  • 相关文献

参考文献14

  • 1Ross R.Atherosclerosis--an inflammatory disease[J].N Engl J Med,1999,340:115-126.
  • 2Hansson GK.Inflammation,atherosclerosis,and coronary artery disease[J].N.Engl.J.Med,2005,352:1685-1695.
  • 3Xiaosong Wang.T-cell co-stimulators as anti-inflammatory targets for atherosclerotic disease[J] Future Medicine,2006,2:187-195.
  • 4Neri Serneri GG,Prisco D,Martini F,et al.Acut T-cell activation is detectable in unstable anginal[J].Circulation,1997,95(7):1806-1812.
  • 5Hansson GK,Holm J,Jonasson L.Detection of activated T lymphocytes in the human atherosclerotic plaque.Am.[J].Pathol.,1989,135,169-175.
  • 6Stemme S,Faber B,Holm J,Wiklund O,Witztum JL,Hansson GK:T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.[J] Proc.Natl Acad.Sci.USA 1995,92,3893-3897.
  • 7Xu Q:Role of heat shock proteins in atherosclerosis.[J] Arterioscler.Thromb.Vasc Biol,2002,22,1547-1559.
  • 8Laurat E,Poirier B,Tupin E et al.:In vivo downregulation of T helper cell 1 immune responses reduces atherogenesis in apolipoprotein E-knockout mice.[J] Circulation,2001,104,197-202.
  • 9Buono C,Pang H,Uchida Y,Libby P,Sharp AH,Lichtman AH:B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice.[J] Circulation,2004,109,2009-2015.
  • 10Schonbeck U,Libby P:CD40 signaling and plaque instability.[J] Circ.Res,2000,89,1092-1103.

同被引文献75

引证文献4

二级引证文献46

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部