摘要
传统的观点认为中枢神经受损后不能再生,然而近年来许多研究证明在一定条件下,中枢神经可以再生。研究发现Nogo蛋白是阻碍中枢神经系统受损后神经元存活和再生的因素之一,它包括Nogo-A、-B、-C三种蛋白,它们主要通过其共有的Nogo-66同受体NgR结合而抑制轴突生长,其中Nogo-A具有最强的抑制神经生长的作用。视神经作为中枢神经系统一部分,其损伤与再生的研究为近年来国内外学者较为关注的热点。本文就Nogo-A与视神经再生的研究进展作一简述。
It was known that the central nerve could not be regenerated, but in recent years, many studies have shown that under certain conditions, it can. Nogo, is a member of the reticulon family of membrane - associated molecules. Three different transcripts（ A, B, C） are originally described as being formed from the gene, coding for three proteins： Nogo - A, Nogo - B, and Nogo - C. They inhibit neurite growth in central nervous system（CNS） through Nogo -66, the common to all three forms, after biding with Nogo receptor（NgR） ,and Nogo -A has the strongest inhibitory effect. As one part of CNS, the optic nerve injury and regeneration have been paid more attention to by a lot of ophthalmologists. In this article, the research on Nogo - A and optic nerve regeneration are reviewed.
出处
《医学信息（中旬刊）》
2010年第2期444-445,共2页
Medical Information Operations Sciences Fascicule
