口腔鳞状细胞癌纤维连接蛋白的免疫组化研究

A immundisto chemisth study on fibronectin in oral sqaumous cell caocnoma

目的研究FN与不同分化程度口腔鳞状细胞癌的关系。方法应用用SPTM免疫组化技术检测了30例口腔粘膜鳞状细胞癌（SCC）和10例正常口腔粘膜纤维连接蛋白（FN）在粘膜基底膜及间质的表达。结果正常口腔粘膜FN的基底膜染色密度低，呈连续线状，间质中染色密度高，呈疏松网状。鳞状细胞癌随肿瘤分化程度的降低，基低膜FN的染色密度升高，间质中FN的染色密度与正常相似。基底膜的染色密度与肿瘤分化程度直接相关，基底膜的连续性与肿瘤的分化程度呈负相关，系数是－0．86。结论FN的表达异常与肿瘤分化、浸润和转移有密切关系。

Objective To Study the ralationship between FN and different exent of progression . oral squmous. MethodThe expression of fibronectin oral squmous cell carcinoma and 10 cases normal mucosa. Results The continuous andweakly staining of basement membrane in normal oral mucosa , whereas in squmnous cell carcinoma intense expression offibronectin was evident in the baswment memb)rane. The expression of fibronectin demonstrated an inverse correlation oncontnuous and showed direct correlation on staining intensity with extent of tumour Progression. Conclusion Alterationsof expression of FN may be related to distintegrate , invation and transfer of carcinoma.