庚型肝炎临床和病理特征

Clinincal and pathological features of hepatitis G

目的探讨庚型肝炎（ＨＧ）临床和病理特征。方法采用逆转录聚合酶链反应（ＲＴ－ＰＣＲ）检测血清ＨＧＶＲＮＡ；用庚型肝炎病毒（ＨＧＶ）ＮＳ５区抗原制备单克隆抗体（ＭｃＡｂ），对２２例临床和／或病理确诊的急、慢性庚型肝炎进行肝脏免疫组化。结果ＨＧＶ感染的血清学模式以重叠ＨＢＶ，ＨＣＶ，ＨＡＶ或ＨＥＶ二重感染为主，占６３．６％（１４／２２），单独ＨＧＶ感染者占３６．４％（８／２２）；ＨＧＶ在肝脏内分布呈散在胞浆型。结论ＨＧＶ单独感染者临床多呈隐匿性发病，症状轻。

Objective To investigate the clinical and pathological features of viral hepatitis G. Methods Twenty two cases of hepatitis G (HG) all with serum HGV RNA positive were clinically and/or pathologically dioganosed. RT PCR were taken for HGV RNA assay. The biopsy tissue from liver were immunohistochemically assayed with HGV NS 5 monoclonal antibody (McAb). Results Eight of 22 patients were infected by HGV only and the other 14 cases were infected by HGV accompanied with any one of HBV, HCV, HEV and HAV infection. The patients infected by HGV only showed slight symptoms and signs without jaundice. The level of transaminase elevated low gradely and liver tissue were slightly damaged. The result of immunohistochemical assay showed positive staining mainly located in cytoplasm. Conclusion HGV can cause hepatitis which may present acute or chronic. Infection with HGV along is frequently asymptomatic or mildly symptomatic and predisposes to chronic.