日本血吸虫感染后血清Ⅵ型胶原水平的动态观察

Monitoring of the serum collagen type Ⅵ in hepatic fibrosis of Schistosomiasis Japanicum

目的了解血清Ⅵ型胶原在评估日本血吸虫病肝纤维化的程度及疗效中的作用。方法对感染日本血吸虫的小鼠和５９例经秋水仙碱或安慰剂治疗的晚期血吸虫病患者血清Ⅵ型胶原水平进行动态观察，同时对小鼠肝脏病理改变及患者肝脏Ｂ超和各临床指标作了观测。结果小鼠血清Ⅵ型胶原水平在感染后进行性升高，并与肝脏病理变化基本一致；患者血清Ⅵ型胶原较正常人也有明显升高（Ｐ＜０．０１），但治疗组在治疗结束后有所下降，而对照组则显著升高，差异有显著性（Ｐ＜０．０１）。结论血清Ⅵ型胶原可能是监测血吸虫病肝纤维化进展及药物疗效的敏感指标。

Objective In order to investigate the value of the surem collagen type Ⅵ in indicating hepatic fibrosis of Schistosomiasis japonic and effects of anti fibrosis theraphy. Methods The levels of serum collagen type Ⅵ were mornitored in murine Schistosomiasis japonica and 59 Schistosomiasis patients treated with colchicine or placebo respectively, pathological changes of mice liver were detected as well as liver B ultrosonic testing and other liver function tests were performed too.Results The levels of serum collagen type Ⅵ increased progressively in infected mice and consisted with pathological changes; colagen type Ⅵ levels in patients were higher than normal level too ( P < 0.01 ). But after treatment collagen levels in treated group decreased slightly whereas increased obviously in control group, the difference were significantly ( P <0.01).Conclusion Serum collagen type Ⅵ maybe a sensitive marker for indicating hepatic fibrosis of Schistosomiasis japonica and for the assessment of the effects of anti fibrosis agents.