血液灌流治疗急性重度百草枯中毒的疗效评价

The Effects of Hemoperfusion on Acute Severe Paraquat Intoxication

目的:探讨血液灌流(HP)在治疗急性重度百草枯中毒中的疗效。方法:回顾性分析83例急性重度百草枯中毒患者的临床资料。其中采用综合治疗的48例为对照组,在综合治疗基础上加HP治疗的35例为治疗组。比较两组检验结果、治愈率与死亡率。结果:两组患者入院后24 h、第3天、第7天的血百草枯浓度、血白细胞、凝血酶原时间、血肌酐、血尿素氮、丙氨酶、肌酸激酶、动脉血氧分压、两组治愈率与死亡率相互比较,差异均有显著统计学意义(P<0.05)。而治疗组内3天血WBC、PT比较,差异没有统计学意义(P>0.05);其余指标比较,差异均有显著统计学意义(P<0.05)。结论:对急性重度百草枯中毒患者尽早进行HP治疗,可提高其治愈率、降低死亡率。

Objective：To investigate the effects of hemoperfusion （HP） on acute severe paraquat intoxication. Methods： 83 patients with acute severe paraquat intoxication were divided into control group （composite therapy without HP, n=48）and treatent group（composite therapy with HP,n=35）.Comparing the laboratory examination results, cure rate and mortality rate. Results： The differences of the PQ,WBC, PT, Cr, BUN,ALT, CK, PaO2 of the first day, the third day, the seventeen day and cure rate, mortality rate were statistically significance （P 〈 0.05）. In treatment group the WBC and PT were not statistically significance （P 〉 0.05）,the others were statistically significance （P 〈 0.05 ）. Conclusion： HP as early as possible is treated on the acute severe paraquat poisoning patients, it can improve the cure rate and reduce the mortality.