奥美沙坦酯对原发性高血压患者血压及左心室肥厚的影响

Effects of Olmesartan Medoxomil in Patients with Primary Hypertension and Left Ventricular Hypertrophy

目的观察血管紧张素Ⅱ型受体拮抗剂奥美沙坦酯对高血压患者血压及左心室肥厚的影响。方法采用前瞻性、随机双盲、阳性药物对照研究方法,将54例原发性高血压合并左心室肥厚的患者随机分为奥美沙坦组(治疗组)27例,口服奥美沙坦酯20mg/d,1次/d;缬沙坦组(对照组)27例,口服缬沙坦80mg/d,1次/d,共24周,服药前后分别测量血压,并行心脏超声检查。结果2组治疗前后血压明显下降(P<0.05);左室后壁厚度(PWT)、左心室舒张期室间隔厚度(IVST)、左室重量指数(LVM I)与治疗前相比有明显的统计学意义(P<0.05),2组间比较无差异性(P>0.05)。结论奥美沙坦酯在降低原发性高血压患者血压的同时,可逆转左心室肥厚。

Objective To investigate the effects of blood pressure angiotensin Ⅱ receptor blocker（ARB）-olmesartan medoxomil in patients with primary hypertension and left ventricular hypertrophy.Methords A total of 54 patients with primary hypertension and left ventricular hypertrophy were randomized into Olmesartan group（given olmesartan medoxomil 20mg daily）and Valsartan group（given valsartan 80mg daily）,for 24 weeks.Blood pressure were measured and heart ultrasonograph were taken before and after treatment.Results Blood pressure、thickness of left ventricular posterior wall and interventricular septum、and left ventricular mass index clearly decreased（P〈0.05）;There was no significant difference between 2 groups（P〈0.05）.Conclusion Olmesartan medoxomil can decrease blood pressure and reverse left ventricular hypertrophy.