小气道功能测定在支气管哮喘与慢性阻塞性肺病中的价值

The Value of Small Airway Inflammation in Asthma and Chronic Obstructive Pulmonary Disease

目的研究小气道功能在支气管哮喘和慢性阻塞性肺病中的临床价值。方法通过观察两组患者舒张实验前后第一秒呼气流量(FEV1)、呼气中段流量(FEF25%～75%)的变化。结果哮喘组经支气管舒张实验FEV1和FEF25%～75%差异有统计学意义,而FEF25%～75%在哮喘组的改善更显著。结论小气道功能可作为区分支气管哮喘和慢性阻塞性肺病的参考指标。

Objective To study the clinical value of the small airway function in bronchial asthma and chronic obstructive pulmonary disease. Methods Before and after the bronchial dilation testing FEV1 （forced expiratory volume in one second）,FEF25%-75% （maximal midexpiratory flow） changes were observed in two groups of patients. Results The asthma groups of patients with FEV1 after bronchial dilation testing,and FEF25%-75% difference was statistically significant（P〈0.01）,while the FEF25%-75% improvement in the asthma group,more pronounced. Conclusion The distinction between small airway function can be used as bronchial asthma and chronic obstructive pulmonary disease,a reference indicator.