中西医结合治疗慢性肾功能衰竭临床分析

Combination of Traditional Chinese Medicine with Western Medicine for Chronic Renal Failure:A Clinical Analysis

目的探讨中西医结合治疗慢性肾功能衰竭(CRF)的临床疗效。方法100例慢性肾功能衰竭患者,分中西医治疗组(A组)50例和西药治疗组(B组)50例,疗程均为8周,观察两组临床疗效及治疗前后血尿素氮(BUN)、血肌酐(Scr)、内生肌酐清除率(Ccr),尿β2微球蛋白(β2-M)、N-乙酰β-D氨基葡萄糖苷酶(NAG)及血清纤维化标志蛋白[Ⅳ型胶原(C-Ⅳ)、Ⅲ型前胶原(PC-Ⅲ)和层黏蛋白(LN)]的含量变化。结果A组总有效率为80.0%,明显高于B组62.0%(χ2=3.987,P<0.05);治疗后A组Scr、BUN、Ccr、β2-M、NAG、C-Ⅳ、PC-Ⅲ和LN均较治疗前明显改善(t=2.125～2.745,P<0.05～0.01);治疗后A组血清纤维化指标较治疗前均明显改善(t=2.175～2.578,P<0.05);治疗后血清纤维化指标两组比较,均有显著性差异(t=2.105～2.478,P<0.05)。结论中西医治疗慢性肾功能衰竭,能提高临床疗效,改善患者肾功能。

Objective To explore the therapeutic effect of combination of Traditional Chinese Medicine（TCM） with Western medicine in the treatment of chronic renal failure （CRF）. Methods We divided 100 cases CRF into combined therapy group （Group A,50 cases）and Western medicine group （Group B,50 cases）,and the treatment of both groups lasted 8 weeks. The therapeutic effect in the two groups was compared,and the blood urea nitrogen（BUN）, serum creatine（Scr）, endogenous creatine clearance rate（Ccr）,urinary β 2 microglobulin （ β 2-M）, 13 -N-acetyglucosamidase （NAG）, serum fibrosis-associated proteins of type Ⅳ collagen （C- Ⅳ）, type Ⅲ precollagen （PC-Ⅲ）and laminin （LN）levels were detected after and after treatment. Results The total effective rate of Group A was 80.0%, significantly higher than that（62.0%） of Group B（ X 2=3-987,P〈0-05）- The levels of SCr,BUN,Ccr, β2-M,NAG, C-Ⅳ ,PC-]iI and LN after treatment were significantly improved compared with those before treatment in Group A（t=-2.125- 2.745, P〈0.05 - 0.01）. The post-treatment serum fibrosis markers were significantly improved compared with pre-treatment in Group A（t=-2.175-2.578, P〈0.05）. The post-treatment serum fibrosis markers in both groups showed a significantly difference（t=-2.105-2.478,P〈0.05）. Conclusion TCM treatment for chronic renal failure can improve the clinical efficacy and renal function.