摘要
丙泊酚（ｐｒｏｐｏｆｏｌ）是一种新型短效静脉麻醉药，具有起效迅速，苏醒快，醒后无宿醉感等优点［１］，因而被广泛地应用于麻醉维持，但其全麻作用的确切机理仍不十分清楚．Ｎａ＋，Ｋ＋－ＡＴＰ酶对维持神经细胞的兴奋性，传导性和影响神经递质的释放等方面具有极为...
Effect of propofol on Na +, K + ATPase and Ca 2+ ATPase activities of cerebral synaptosomes was investigated in rats. It was found that propfol 50 mg·kg 1 ip significantly inhibited Na +, K + ATPase activity of hippocampal and brain stem′s synaptosomes (P<0.01). Propofol 100 mg·kg 1 ip significantly reduced Na +, K + ATPase and Ca 2+ ATPase activity of cerebrocortical, brain stem′s and hippocampal synaptosomes (P<0.01). It is suggested that the central inhibitory effect of propofol may be related to the inhibition of Na +, K + ATPase and Ca 2+ ATPase activity of cerebral synaptosomes.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1998年第4期310-311,共2页
Chinese Journal of Pharmacology and Toxicology
基金
国家自然科学基金
关键词
丙泊酚
麻醉药
脑突触体
钠
钾
ATP酶
酶活
propofol
adenosine triphosphatase
sodium
potassium
adenosine triphosphatase
calcium
synaptosomes
