子宫内膜癌端粒酶活性研究

Telomerase activity in human primary endometrial carcinoma

目的探索端粒酶活性与子宫内膜癌发生发展的关系。方法采用ＰＣＲ－ＴＲＡＰ方法检测３４例子宫内膜癌和６例正常子宫内膜组织的端粒酶活性。结果在３４例子宫内膜癌中，２８例端粒酶活性阳性；６例正常子宫内膜组织中，有１例端粒酶活性阳性。结论端粒酶激活与子宫内膜癌的发生发展有密切关系。

Objective To investigate the possible relationship between telomerase expression and progression of endometrial carcinoma. Methods Thirty four primary endometrial carcinoma and 6 normal endometrial tissue specimens were examined by means of telomeric repeat amplification protocol (TRAP) assay for telomerase activity. Results Of 34 endometrial cancer specimens, 28 (82.4%) showed telomerase activity, whereas 1 of 6 (16.7%) benign endometrial tissues exhibited telomerase activity. Conclusion Telomerase expression might contribute to the progression of endometrial carcinoma and could be used as its tumor marker.