摘要
应用单抗免疫组化技术检测50例胃癌手术切除的标本,探讨 MMP-TIMP 在两型胃癌组织中的分布和含量的变化,并分析其表达水平与肿瘤的淋巴结转移、远处转移以及患者生存率之间的关系。结果发现,MMP-2在早期肠型胃癌组织中表达量少,进展期阶段明显增高,尤其是弥漫型;MMP-9在进展期肠型胃癌组织中表达量较高;TIMP-2则以早期肠型胃癌组织中表达量为高。较早死于肿瘤转移的患者,不论其肿瘤组织学类型和疾病分期,其瘤组织中均有较高的 MMP-2的表达和较低的 TIMP-2的表达。结果表明,MMP-2及 TIMP-2的表达对判断胃癌患者的预后有重要意义。
The presence of MMP-2、MMP-9 and TIMP-2 protein in 50 gastric tumor samples with various degree of differentiation and staging was evaluated by using the immunohistochemical technique.The relationship between the expression of those proteins and LN metastasis,distant metastasis of tumor,and survival time of cancer patients was also studied.The results showed that MMP-2+ cells were present in a small portion in intestinal type EGC.There was an increased expression of MMP-2+ cells in AGC,especially in the diffuse type carcinoma;MMP-9+cells was often increased in the intestinal type as compared with the diffuse type of AGC.In intestinal type EGC,TIMP-2 was expressed by the majority of tumor cells.More higher expression of TIMP-2 was found in intestinal type EGC when compared with diffuse type gastric cancer.In patients who died from metastasis,there was a high percentage of MMP-2+ cells and a low percentage of TIMP-2+ cells.We believe evaluation of MMP-2 and TIMP-2 is highly valuable in defining prognosis for gastric cancer patient.
出处
《上海第二医科大学学报》
CSCD
1998年第6期472-475,共4页
Acta Universitatis Medicinalis Secondae Shanghai
基金
卫生部科学研究基金资助课题(94-2-249)
