环丙氨嗪合成工艺研究

The Synthesis of Cyromazine

以三聚氯氰为原料经过环丙胺化和液氨氨化二步合成环丙氨嗪,总收率达88.11%。不用分离出剧毒的中间体2-环丙氨基-4,6-二氯-S-三嗪,工艺简单。在液氨氨化体系中添加溶剂乙醇,缩短了反应时间,提高了产品质量和反应收率,具有较高的工业生产价值。

Cyromazine was prepared by cyclopropylamination and amination from cyanuric chloride in total yield of 88.11%. In this process, highly toxic intermediate 2-cyclopropylamino-4,6-dichloro-s-triazine was not isolated, and ethanol was add to the reaction for decreasing the reaction time and improving the yield. The reaction conditions were optimized. The advantages of this process include short reaction time, simple work-up operation and apt to be scaled up.