摘要
探讨了合成(S)-1-(2-氯乙酰基)吡咯烷-2-甲腈的新工艺路线,即以L-脯氨酸为原料,经N-氯乙酰化、羧基氨基化和酰胺脱水反应合成目标化合物。目标化合物及各中间体的结构采用1HNMR和MS进行了确定。此外,详细研究了反应条件的影响,得到了优化的反应条件。目标产物的总收率可达42.3%。该合成路线具有原料便宜易得、操作简单、条件温和等优点,具有很好的市场应用前景。
（S）- 1- （2-Chloroacetyl） pyrrolidine-2-carbonitrile was synthesized from L-proline via the processes ot N-chloroacetion, cabboxyl amination and earboxamide dehydration. The structures of the intermediates and the target compound were confirmed by 1H NMR and MS. Effect of the process conditions on reaction was investigated and the optimum parameters were obtained. The target compound was achieved in an oveval yield of 42.3%. The synthetic route has advantage of lower cost, simple operation and mild reaction condition.
出处
《精细化工中间体》
CAS
2010年第1期27-30,共4页
Fine Chemical Intermediates
