不同年龄健康人血β痕迹蛋白与肾小球滤过率以及颈动脉内中膜厚度的相关性探讨

Relationship Between Serum β-trace Protein Components and Glomerular Filtration Rate or Carotid Intima-media Thickness in Healthy People of Different Age

【目的】了解不同年龄健康个体血β痕迹蛋白（β-TP）与肾小球滤过率（GFR）和血管硬化的关系。【方法】82名健康志愿者，按年龄分为3组：A组，35～岁（30例）；B组，50～岁（27例）；C组，≥70岁（25例）。用MDRD公式估算GFR，即eGFR；行颈动脉彩超检查，测量颈动脉内膜-中膜厚度（C—IMT）；应用酶联免疫法测定β-TP的浓度。【结果】①eGFR随年龄增长而降低，≥70岁组同其他二纽相比，eGFR明显下降（P〈0．05）。男，女性eGFR降低在70岁以后才开始出现统计学差异（P〈0．01）；50～岁及70岁以上两个年龄段男性eGFR比女性低，35～岁段较女性高，但这种差异性无统计学意义（P〉0．1）。②C-IMT随年龄增长而增加，≥70岁组与其他二组相比，C—IMT明显增加（P〈0．05）。男性和女性C—IMT增加趋势一致，均在70岁以上出现统计学差异（P〈0．05）。③eGFR与C—IMT呈负相关。④血β-TP在各年龄组间及不同性别间均无统计学差异（P〉0．1），血β-TP与eGFR及C—IMT无相关性（P〉0．1）。【结论】不同年龄各组血β-TP浓度无明显变化，且不随eGFR及CIMT变化，其不能做为预测衰老和血管硬化的指标。

[Objective]To explore the relationship between serum β-trace protein（β-TP） and glomerular filtration rate（GFR） or arteriosclerosis in healthy people of different ages. [Methods]According to the age, 82 healthy volunteers were divided into Group A（ n =30, aged 35 years old）, group 13（ n =27, aged 50 years old） and group C（ n =25, aged≥70 years old）. GFR（eGFR） was calculated by MDRD formula. Carotid inti ma-media thickness（C-IMT） was measured by carotid artery color Doppler ultrasound. β-TP was detected by ELISA. [Results]eGFR decreased with the age. The decrease of eGFR in both male and female patients had significant difference in group C（ P d0.01）, eGFR in male patients of group B and group C was lower than that in female patients, eGFR in male patients of group A was higher than that in female patients, but there was no significant difference（ P 〉0. 1）. As compared with other two groups, C-IMT increased with the age（ P 〈0.05）. The increase of C-IMT in male patients was similar to that in female patients. There was statistical difference in the increase of C-IMT in group C between male and female patients （ P 〈0.05）. The correlation between eGFR and C-IMT was negative. There was no statistical difference in serum β-TP among groups of different age and sex（ P 〉0.1）. There was no correlatin between serum β-TP and eGFR or C-IMT（ P 〉0. 1）. [Conclusion]Serum β-TP has no change in groups of different age and does not alter with the changes of eGFR and C-IMT. Therefore it is not as the marker for predicting the aging. Serum 13-trance protein can＇t be the aging and arteriosclerosis.