摘要
【目的】比较蔗糖铁与右旋糖酐铁注射液静脉注射治疗维持性血液透析(MHD)患者缺铁性贫血的疗效与安全性。【方法】100例MHD患者随机分为试验组(蔗糖铁组)与对照组(右旋糖酐铁组),每组各50例。将100mg蔗糖铁和100mg右旋糖酐铁分别稀释100mL生理盐水,于每次血液透析时使用。每周治疗1次,治疗时间为10周,观察12周。两组患者的总铁量1000mg,所有病例都合并使用促红细胞生成素(EP0)治疗,剂量为每周120~150u/kg,皮下或者静脉应用。观察并比较两组患者治疗贫血的效果,铁代谢指标的变化及不良反应发生的情况。【结果】两组的血红蛋白(Hb)均较治疗前显著升高(均P〈0.01);红细胞比容(HCT)也较治疗前显明升高(均P〈0.01),而试验组的上升幅度大于对照组,但两组相比较差异无统计学意义(均P〈0.01)。两组血清尿素氮、肌酐、转氨酶等均无明显变化。两组患者均无严重的不良反应发生。【结论】蔗糖铁是治疗伴有缺铁性贫血血液透析患者的一种安全有效的药物。
[Objective]To investigate the efficacy and safety of intravenous iron sucrese injection and iron dextran for the treatment of iron deficiency in renal anemia in maintenance hemodialysis (MHD) patients. [Methods]In this prospective randomized controlled multi-center clinical study, 100 MHD patients were divid ed into treatment group (iron sucrese injection group, n = 50) and control group (iron dextran group, n = 50). The patients were treated with intravenous iron sucrese injection or iron dextran 100mg during 10 consecutive hemodialysis sessions, once a week for 10 weeks. The follow-up was 12 weeks. The total supplement iron amount of both groups was 100mg. Erythropoietin(EPO) was used at a dose of 120-150 u/(kg · week). The efficacy and safety were assessed by evaluating the change of Hb; ferritin and the side effects in both groups before and after treatment. [Results] Compared with the pre-treatment, Hb and HCT in both groups increased significantly( P 〈0.01), and those in treatment group were higher than those in control group, but there was no significant difference( P 〈0.01) between two groups. BUN, SCR and AST in serum in both groups had no obvious change. No severe complication happened in both group. [Conclusion] Intravenous iron sucrese injection is effective and safe for the treatment of iron deficiency in hemodialysis patients.
出处
《医学临床研究》
CAS
2010年第2期291-294,共4页
Journal of Clinical Research