连续血液净化治疗急性重症胰腺炎的临床疗效分析

Clinical Analysis of Acute Severe Pancreatitis Patients Treated with Continuous Blood Purification

【目的】观察并分析连续血液净化治疗急性重症胰腺炎（sAP）的效果。【方法】回顾性分析本院1998-2009年期间采用连续性静-静脉血液滤过（CVVH）方法治疗SAP75例的临床资料，比较患者治疗前后临床表现，血清尿素氮（BUN）、肌酐（SCr）、APACHEⅡ评分的变化。【结果】75例患者均很好的耐受治疗。经过连续血液净化治疗，患者的临床表现及血液生化检验指标、APACHEⅡ评分等均有明显改善，大大降低了SAP的病死率。【结论】连续性血液透析滤过可成为SAP患者重要而安全可靠的治疗措施。

[Objective]To observe and analyze the efficacy of continuous blood purification （CBP） in the treatment of acute severe pancreatitis（SAP） patients. [Methods] Seventy five patients with SAP underwent CBP from 1998 to 2009. Continuous veno-venous hemofiltration （CVVH） was performed. Clinical signs, serum urea nitrogen （BUN）, serum creatinine （Scr）, and acute physiology and chronic health evaluation （A- PACHEⅡ ） before and after treatment were compared. [Results]CVVH was well tolerated in all of the patients. Compared with those before treatment, .clinic signs were improved, and BUN, Scr and APACHE Ⅱ were decreased significantly. The mortality rate was greatly lower. [Conclusion] Continuous blood purification therapy is safe and effective for acute severe pancreatitis patients.