福辛普利联合合贝爽对老年单纯收缩期高血压患者疗效观察

Effect of Fosinopril and Herbesser Combined Medication Isolated Systolic Hypertension

目的探讨合贝爽联合福辛普利治疗单纯收缩期高血压(ISH)的效果观察。方法选取90例单纯收缩期高血压患者,分别用合贝爽、福辛普利、合贝爽和福辛普利联合治疗组治疗12周,观察治疗前后血压,大小动脉弹性功能指数(C1、C2),尿α1-微球蛋白、尿微量白蛋白的变化。结果联合治疗组的疗效要显著高于福辛普利组和合贝爽组。治疗后,三组患者血压及心率均显著下降。同组治疗前后比较,差异均有统计学意义(P<0.05)。联合治疗组与合贝爽组比较,联合治疗组可显著降低单纯收缩期高血压患者的收缩压和脉压差(P<0.05);而与福辛普利组比较,脉压差也获显著改善(P<0.05),但收缩压改善程度无差异(P>0.05)。三组的舒张压水平差异无统计学意义(P>0.05)。三组尿α1-微球蛋白、尿微量白蛋白水平均较治疗前显著降低(P<0.05)。联合治疗组与福辛普利组和合贝爽组比较,联合治疗组尿α1-微球蛋白及尿微量白蛋白水平均显著降低,差异具有统计学意义(P<0.05)。结论合贝爽联合福辛普利在控制单纯收缩期高血压患者收缩压,降低尿α1-微球蛋白、尿微量白蛋白,改善动脉弹性功能方面均具有协同作用。

Objective To evaluate the effect of fosinopril and herbesser combined medication on blood pressure and proteinuria in patients with isolated systolic hypertension（ISH）. Methods 90 patients with ISH were randomly divided into 3 groups： fosinopril group, herbesser group and combined medication group. The treatment course was 12 weeks, Blood pressure, urine α1-microglobin and microalbuminuria were detected before and after the treatment. Results After 12 weeks treatment,the effect of the combined medication group was better than the fosinopril group and the herbesser group. The systolic blood pressure（SBP）, diastolic blood prcssure（DBP） and heart rates were significantly decreased in all groups（P〈0.05）. SBP had greater reduction in combined medication group than each of the single medication group（P〈O.05）. The levels of urine α 1-mieroglobin and microalbuminuria were decreased in all groups, while the combined group had the most significant reduction（P〈0.05）. Conclusion Fosinopril and herbesser combined mediation indicated the additive effects to decrease blood pressure,urine α1-microglobin andmicroalbuminuria in patients with ISH.