乳腺癌组织中nm23和P53的表达与浸润转移的相关性研究

Correlation of nm23 and P53 Expression in Breast Tissue with Invasion and Metastasis

目的探讨乳腺癌组织中nm23和P53的阳性表达与浸润转移的关系。方法选取2006年2月～2009年2月我教研室乳腺癌标本60例,采用免疫组化法检测nm23与P53蛋白的阳性表达情况。结果①nm23、P53在60例乳腺癌组织中阳性表达率分别为85.0%(51/60)、53.3%(32/60)%。②nm23阳性表达随组织学分级升高而降低(P<0.05),且有淋巴结转移组nm23的阳性表达率较无淋巴结转移组低(P<0.05),P53阳性表达与组织学分级有关(P<0.05)。③nm23和P53的表达二者间差异有统计学意义(χ2=4.22,P<0.05)。经Spearman等级相关分析显示,两者在乳腺癌组织中的表达呈负相关(r=-0.480,P<0.05)。结论乳腺癌组织中nm23和P53的表达可作为乳腺癌浸润转移潜能的判断指标之一,具有重要的临床意义。

Objective To explore the relationship between the positive expression of tissue P53 and nm23 in breast cancer and the invasion and metastasis. Methods We selected 60 cases of breast cancer specimens in our department from Feb. 2006 to Feb. 2009 and used immunohistoehemical staining to detect the positive expression of rim23 and P53. Results The positive expression rates of tissue nm23 and P53 in 60 cases of breast cancer were 85.0%（51/60） and 53.3%（32/60）,respectively. The positive expression rate of tissue nm23 was lowered with increased histological grading （P〈0.05）. The nm23 positive expression rate in lymph node metastasis was lower than that without lymph node metastasis（P〈0.05） and the P53 positive expression was correlated with histological grading（P〈0.05）. There was a significant difference between nm23 expression and P53 expression（ X^2=4.22,P〈0.05 ）. Spearman rank correlation analysis showed a negative correlation in the expression of both in breast cancer tissue（ r=-0.480,P〈0.05 ）. Conclusion The expression of tissue nm23 and P53 in breast cancer can be used as one of the indicators for the invasive and metastatic potential of breast cancer,which is of important clinical significance.