摘要
脑缺血是临床上常见的疾病,它能造成神经元损伤,影响神经功能。神经干细胞在一定条件下可增殖分化成神经元和胶质细胞,缺血性脑损伤后能参与神经功能的修复过程。本文对神经发生的机制和影响因素、缺血后的神经发生与脑功能恢复的联系,以及药物促进神经发生在脑缺血疾病治疗中的应用及前景进行文献综述。
Neural stem ceils (NSCs), which will proliferate and differentiate into neurons and glial cells under certain conditions, involved in the repair of neurological function. This process is called neurogenesis. Focal cerebral ischemia-reperfusion injury is one of the most common diseases, which can induce the neurological functional deficits. It is significant to study the response and regulation of NSCs after focal cerebral ischemiareperfusion injury, In this article, we reviewed the characteristics, molecular mechanisms, putative endogenous mediators and exogenous stimulators of neurogenesis in adult brain following ischemic injury, and response and regulation of drug in ischemic injury following neurogenesis.
出处
《中国康复理论与实践》
CSCD
2010年第2期103-105,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
"重大新药创制"科技重大专项(2009ZX09103-366)
国家自然科学基金项目(30740053
30973893)
北京市自然科学基金项目(7062031)
关键词
脑缺血再灌注
神经发生
药物
综述
cerebral ischemia-reperfusion
neurogenesis
drug
review