摘要
目的探讨HLA-DPB1等位基因对广西汉族重症肌无力(MG)的遗传易感性。方法用限制性片段长度多态性(PCR-RFLP)多酶共同消化法对HLA-DPB1的31个等位基因进行分型。结果发现广西汉族MG患者的HLA-DPB10501及3601的频率明显高于正常人。DPB12701在全身型MG明显增多。DPB1易感基因为纯合子时,MG发病早,并与全身型MG密切相关。早发病MG与晚发病MG、男性MG与女性MG、眼肌型MG与全身型MG的HLA-DPB1遗传背景有所不同。结论广西汉族MG的HLA-DPB1易感基因为0501、3601及2701,其中前两者对MG发病最重要。
Objective To investigate the HLA-DPB 1 allele genetic susceptibility in myasthenia gravis (MG) patients of Han nationality in Guangxi , China. Methods Thirty-one HLA-DPB 1 alleles in 28 MG patients and 20 controls of Han nationality were investigated by co-digesting of PCR-RFLP. Results The frequencies of HLA-DPB 1 0501 ( P <0.05) and 3601 ( P <0.05) were significantly increased in the MG patients compared to healthy controls. The frequency of DPB 1 2701 was significantly increased in general MG ( P <0.05). The homozygotes of susceptive gene were associated with the early-onset MG and general MG. The genetic background of the late-onset MG, male MG and ocular MG was different from that of the early-onset MG, female MG and general MG. Conclusions These results indicate that HLA-DPB 1 0501, 3601 and 2701 play key roles in the MG process of Han nationality.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1998年第6期353-355,共3页
Chinese Journal of Nervous and Mental Diseases
基金
广西自然科学基金
关键词
重症肌无力
HLA-DPB1
等位基因
遗传易感性
Human leukocyte antigen DPB 1
Han nationality
Myasthenia gravis
Genetic susceptibility