压力负荷增加大鼠模型血浆内皮素水平的改变

Changes of the plasma endothelin in rats with pressure overload

目的:观察压力负荷增加对大鼠血浆内皮素水平的影响。方法:采用腹主动脉狭窄法所致压力负荷增加诱发大鼠左室肥厚模型,观察左室重量指数(LVMI),采用放射免疫分析法检测血浆内皮素水平。结果:LVMI模型组明显高于假手术组(P<0.01);血浆内皮素水平模型组较假手术组显著升高(P<0.01)。结论:腹主动脉缩窄所致压力负荷增加可诱发大鼠左室肥厚,该作用可能与血浆内皮素水平升高有关。

Objective： To observe the effects of pressure overload on level of plasma endothelin, and study the possible mechanism of left ventricular remodeling. Methods： left ventricular mass index （LVMI） and plasma endo- thelin were measured in the rat models with myocardial hypertrophy of chronic heart failure and pressure overload by abdominal aortic constriction by radioimmunoassay. Results： LVMI in the model group was obviously higher than that of the sham group（ P 〈 O. O1 ）. The plasma endothelin levels in the model group were obviously higher than those of sham group（ P 〈 O. O1 ）. Conclusion： pressure overload by abdominal aortic constriction can induce left ventricular remodeling in chronic heart failure, the mechanism of left ventricular remodeling might be related to the upregulated endothelin levels in plasma.