氟康唑治疗孢子丝菌病的临床疗效及体外抗真菌药敏试验研究

Evaluation of the Clinical Efficacy of Fluconazole to Sporotrichosis and the Antifungal Susceptibility in Vitro

目的观察氟康唑对孢子丝菌病的临床疗效,检测孢子丝菌对氟康唑、伊曲康唑的体外敏感性,探讨孢子丝菌病治疗的新方法。方法对60例孢子丝菌病患者给予氟康唑片口服治疗[成人首次100mg,以后50mg,儿童3～5mg/(kg.d)],30例患者给予10%碘化钾溶液10mL口服治疗,并采用E-test法检测其中10株孢子丝菌对氟康唑和伊曲康唑的最小抑菌浓度(MIC)。结果氟康唑组有效率为95.00%,碘化钾组为86.67%。采用E-test法检测10株孢子丝菌对氟康唑和伊曲康唑的MIC值,范围分别为>256μg/mL,0.012～8.0μg/mL。结论氟康唑对孢子丝菌病有较好的临床疗效,但申克氏孢子丝菌对对氟康唑的体外敏感性较低。E-test法可以作为一种孢子丝菌的体外抗真菌药敏试验方法。

Objective To investigate the clinical efficacy of fluconazole in the treatment of Sporotrichosis and the susceptibility of fluconazole and itraconazole to Sporothrix schenckii in vitro, to study a new method in the treatment of Sporotrichosis. Methods 60 cases of patients with Sporotrichosis were given fluconazole tablets for three months . As a control, 30 patients with Sporotrichosis were given 10% KI for three months. The MIC of fluconazole and itraconazole for 10 isolates of Sporothrix schenckii were determined by the E-test. Results The effective rate of treatment and control group were 95.00% and 86.67% respectively. The MICs of fluconazole and itraconazole tothe 10 clinical isolates determined by the E-test were 〉 256μg/ml and 0.012 8.0μg/ml respectively. Conclusions The studies suggest that fluconazole is an effective method in the treatment of Sporotrichosis. E-test may be a good test for determining antifungal susceptibility of some antifungal agents to Sporothrix schenckii.