矿泉浴联合5%松馏油软膏治疗银屑病的疗效观察

Observation on Therapeutic Effect of Mineral Spring Baths Combined with 5% Pine Tar Ointments in the Treatment of Psoriasis Vulgaris

目的观察矿泉浴联合5%松馏油软膏封包治疗寻常性银屑病的疗效和安全性。方法将150例寻常性银屑病患者分为两组,均采用5%松馏油软膏封包治疗,1次/d,治疗组同时采用矿泉浴治疗,1次/d,30min/次,两组疗程均为6周。在治疗后3,6周根据PASI评估疗效。结果治疗3周时,治疗组PASI评分下降值显著高于对照组(P<0.01)。疗程结束时,治疗组有效率为91.00%,对照组有效率为70.00%,两组比较差异有显著性(P<0.01)。治疗组和对照组的不良反应发生率分别为15.00%和26.00%,两组差异无显著性(P>0.05)。两组疗法都未出现系统不良反应。结论矿泉浴联合5%松馏油软膏封包治疗寻常性银屑病疗效好,能迅速缓解病情,是一种安全有效的治疗方法。

Objective To observe the efficacy and safety of mineral spring baths combined with 5% pine tar ointments in the treatment of psoriasis vulgaris. Methods 150 patients with psoriasis vulgaris were randomly divided into two groups. The two groups were all treated with 5 % pine tar ointments containing bandages, one time per day. Meanwhile the treatment group were treated with mineral spring baths, one time per day, thirty minutes of one time. The two groups courses were 6 weeks. Treatment assessment was carried out in 3,6weeks, which was based on the Psoriasis Area and Severity Index （PASI） score. Results It had proved a siganificant reduction of PASI in the treatment group in comparison with the control group after treatment of 3weeks. At 6weeks, the effective rate of the treatment group was 91.00%, and the control group was 70.00%. The effective rate between two groups had significant difference （ p 〈0.01）. Besides, untoward reaction incidence rate was found 15.00% in the treatment group and 26.00% in the control group, while no systemic adverse event had been observed in either group. Conclusion Combining mineral spring baths with 5.00% Dine tar ointments is an efficacy and safety topically applied agent in the treatment of psoriasis vulgaris.