无菌性脓疱病102例临床分析

Clinical analysis of 102 cases of aseptic pustulosis

目的:探讨无菌性脓疱病的临床表现及有效的治疗方法。方法:回顾性分析昆明医学院第一附属医院皮肤科1982年11月—2008年11月收治的102例住院无菌性脓疱病患者的病历资料。结果:在102例患者中,泛发性脓疱性银屑病67例,掌跖脓疱病6例,连续性肢端皮炎5例,疱疹样脓疱病24例。系统表现中常伴发热和白细胞升高。治疗主要是昆明山海棠、维A酸类药物、免疫抑制剂、非特异性抗炎药、糖皮质激素。临床治愈率为63.73%,有效率为85.29%。死亡3例。结论:无菌性脓疱病主要采用昆明山海棠、阿维A、非特异性抗炎药、免疫抑制剂治疗,应尽量避免系统使用糖皮质激素。

Objective： To study the clinical characteristics and therapeutic effects of aseptic pustulosis. Methods： The clinical data on 102 cases of aseptic pustulosis collected from dermatology department of the First Affiliated Hospital of Kunming Medical College from November 1982 to November 2008 were analyzed retrospectively. Results： Among these 102 cases, there were 68 pustular psoriasis, 6 palmoplantar pustulosis, 5 aerodermatitis continua and 24 impetigo herpetiformis. It was found that the significant causative factors of pustular psoriasis were upper respiratory infection and irregular use of glueocortieoid. The primary systematic manifestations were fever and leucocytosis. The therapies were including Tripterygium hypoglaucum, retinoie acid, immunosuppressant, non-specificity anti-inflammatory agents, and glucoeortieoid. The clinical cure rate was 63.73%. The total response rate was 85.29%. Three dead cases were recorded. Conclusion： Ripterygium hypoglaucum, retinoie acids, non-specificity anti-inflammatory agent, and immunosuppressant are the main therapeutic drugs for pustular psoriasis. Glucocorticoid is not the first choice.