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建立小鼠硬皮病模型的实验性研究 被引量：1

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摘要 硬皮病是一种以局限性或弥漫性皮肤硬化或伴有内脏器官纤维化为特征的结缔组织病。此病发病机制不明，治疗困难，给患者带来痛苦。近年来，许多学者用局部注射博莱霉素建立小鼠硬皮病模型，我们为研究此方法的可重复性及筛选合适的博莱霉素造模剂量，为后期新药实验做准备，特进行该实验，现将实验过程、方法介绍如下。
作者 米新陵 李凡 华伟 惠艳 杨克健
机构地区 新疆克拉玛依市中心医院皮肤科 新疆医科大学第一附属医院皮肤科
出处 《中国麻风皮肤病杂志》 2010年第2期125-127,共3页 China Journal of Leprosy and Skin Diseases
关键词 实验性研究 硬皮病 模型 小鼠 博莱霉素 结缔组织病 器官纤维化 病发病机制
分类号 R-332 [医药卫生] R593.25 [医药卫生—内科学]
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参考文献16

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二级参考文献24

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共引文献23

同被引文献13

  • 1黎智,阎国富,胡美玲,何云志,黄海,何威.局部注射博莱霉素诱导小鼠硬皮病模型[J].重庆医学,2004,33(12):1821-1823. 被引量：6
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  • 5Review. Asano Y, Sato S. Animal models of scleroderma: current state and re- cent development[J]. Curr Rheumatol Rep,2013,15(12) :382.
  • 6Yarnamoto T. Takagawa S, Katayama I,et al. Animal model of sclerotic kin. I: local injections of bleomycin induce sclerotic skin mimicking sclerederma [ J ]. J Invest Dermatol, 1999,112:456 -462.
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  • 10Maurer B, Reich N, Juengel A ,et al. Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis [J]. Ann Rheum Dis, 2012,71:1382-1387.

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中国麻风皮肤病杂志
2010年 第2期

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